We are excited to have Julia Brosch visiting us from LMU (Ludwig Maximilian University of Munich). Julia obtained her BSc (physics) in 2014 (thesis: multi-phase tracer kinetics in Lutetium-177-DOTATATE therapy of NETs for optimized kidney dosimetry) and MSc (medical physics) in 2017 (thesis: dosimetric approaches for Yttrium-90 SIRT based on quantitative SPECT and PET images). Julia started her PhD in November 2017, and is part of the research training group GRK2274. Her overall research involves Monte Carlo based dosimetry for radionuclide therapy with focus on Lutetium-177-PSMA therapy. During her stay with us, she aims to learn how to use GATE for simulation of 3D dose distributions for Lu-177-PSMA, and to investigate differences in doses to organs at risk using different dosimetric approaches. We are already very impressed by Julia’s enthusiasm and depth of knowledge.
Category: Interesting links/news
We are pleased to announce being awarded a CIHR project grant. Our proposal (funded for 4 years; $631,124) is entitled, “Quantitative PSMA Targeted Imaging of Prostate Cancer Patients”. We aim to improve assessment of disease for prostate cancer patients in the context of our ongoing clinical trials involving prostate-specific membrane antigen (PSMA) radioligand therapy (also known as radiopharmaceutical therapy). We will pursue advanced PSMA PET data acquisition (particularly dynamic whole-body imaging), as well as improved image reconstruction and enhancement. Our efforts will also involve automated deep-learning based segmentation of PET images, as well as predictive modeling of prostate cancer using radiomics and machine learning methods.
Dr. Anna Celler is the recipient of the Gold medal this year by the Canadian Organization of Medical Physicists (COMP), which is being celebrated tomorrow (September 14) in Montreal. Anna taught the very first course I (Arman) took in the field of nuclear medicine. She has had 27 years of tireless efforts, having mentored many students in her Medical Imaging Research Group, and made contributions on multiple frontiers in nuclear medicine. What makes Anna especially stand out in my mind is how much she cares about the well-being of the students she works with, and how she has fought through the years to establish a legacy of research and service at our institutions. Anna retired recently, though thankfully visiting on a regular basis. I hope that we can carry forward a part of Anna’s legacy, and I’m grateful that she will continue to work with us and advise us as we set a path forward. Thank you Anna!
After 13 years at Johns Hopkins University, our lab is moving to Vancouver in July! Our lab will be jointly affiliated with the Departments of Radiology and Physics & Astronomy at the University of British Columbia (UBC), as well as the BC Cancer Agency (BCCA). We look forward to playing an active role in concerted and integrated efforts to improve research, education and clinical practice at UBC and BCCA. Hopkins, as an amazing institute and community, has been extremely gracious to us, to which we’re indebted, and we surely hope and plan to pursue significant collaborations and joint efforts.
Finally, there is a vendor product (FlowMotion Multiparametric PET by Siemens) that enables dynamic whole-body PET including parametric imaging. This is very rewarding given that our group was the earliest to propose and work on this framework, including close collaboration with Siemens. This is clearly an enabling technology, and it remains to be seen whether it will add significant value to routine clinical imaging. Hopefully more and more centers will try and explore potential benefits from this technology.
Our book has now been finally published: “Nuclear Medicine Physics: The Basics” (Paperback)
Authors: Ramesh Chandra and Arman Rahmim
Publisher: Wolters Kluwer (Nov. 2017; Philadelphia, PA)
Overview: Part of the renowned The Basics series of medical physics books, and originally authored by Dr. Chandra decades ago, this has been a classic text for nuclear medicine, molecular imaging and radiology residents, fellows and practitioners, medical physicists and radiologic technologists. This newly co-authored effort has lead to a substantially updated and expanded 8th edition.
The book covers a wide range of topics on radioactivity, radiopharmaceuticals, in vitro and in vivo detection, radiation dosimetry/risk/regulations, imaging devices (gamma camera, SPECT, PET), quality assurance, image reconstruction/processing, etc., with 18 chapters:
- Basic Review
- Nuclides and Radioactive Processes
- Radioactivity: Law of Decay, Half-Life, and Statistics
- Production of Radionuclides
- Interaction of High-Energy Radiation with Matter
- Radiation Dosimetry
- Detection of High-Energy Radiation
- In Vitro Radiation Detection
- In Vivo Radiation Detection: Basic Problems, Probes, and Scintillation Camera
- Computer Interfacing and Image Processing
- Operational Characteristics and Quality Control of a Scintillation Camera
- Emission computed tomography (ECT), General Principles
- Single-Photon Emission Computed Tomography (SPECT)
- Positron Emission Tomography (PET)
- Detectability or Final Contrast in an Image
- Biological Effects of Radiation and Risk Evaluation from Radiation Exposure
- Methods of Safe Handling of Radionuclides and Pertaining Rules and Regulations