Our recent publication on the impact of respiratory motion correction for ejection fraction (EF) measurements in cardiac PET has now been features as a news article on medicalphysicsweb. The findings of this work reiterate the significant potential of respiratory motion correction for this important clinical imaging task.
Our article on dynamic whole-body imaging has been ranked among top 10 most popular articles in the journal of Physics in Medicine & Biology (PMB) in 2016. The work was also featured on medicalphysicsweb in a piece titled “A clinical take on whole-body dynamic PET“. The work is creating excitement in its potential to transform routine clinical imaging, to enable dynamic PET imaging while still providing conventional whole-body standard uptake value (SUV) images.
This is a good piece (Siemens) outlining a new direction in PET imaging: Think Whole-body Dynamic PET Imagings for Research Only? Perhaps it’s Time to Re-evaluate. Also see an example dynamic imaging animation. Our group was the earliest one to propose (in 2011) and extensively publish this promising approach (e.g. companion papers in 2013, and onwards). It is very rewarding to see that this framework may be translated to clinical practice, thanks to efforts of multiple groups that are now pursuing it.
Our recent publication in the journal Neurology has been accompanied by a nice editorial reviewing and discussing the novel finding. This work involved recruitment of subjects from the longitudinal Atherosclerosis Risk in Communities (ARIC) study, for an additional PET scan to visualize amyloid in the brain, which has been a major breakthrough in the field of Alzheimer disease (AD). The resulting ARIC-PET amyloid imaging study revealed for the first time that black subjects depicted higher amyloid levels, even after adjustment for demographics, vascular risk factors, and cognitive status, making the provocative suggestion that there might be race differences in the process of amyloid deposition.
The analysis itself was stimulated by reports of increased prevalence of AD in black compared to white individuals. In this major NIH funded effort (PI: Gottesman), extensive site travel, quality assurance and quantitative analysis was performed by Chief Physicist Dr. Rahmim for data obtained from the three PET imaging sites (Washington County, MD; Jackson, MS; and Forsyth County, NC).
The following point/counterpoint was just published in Med. Phys. It was a fun and interesting piece to write, and both Adam and I seem to have converged towards the end on a need for careful assessment of this issue within a task-based framework. It’s a short piece with lots of concise observations:
A. M. Alessio, A. Rahmim, and C. G. Orton (Moderator)
Resolution modeling enhances PET imaging
Med. Phys., vol. 40, pp. 120601, 2013.
Here we hope you will find useful information about the various things that go on in our lab.