Category: New publication

New Book Finally Published!

Our book has now been finally published: “Nuclear Medicine Physics: The Basics” (Paperback)

cover

Authors: Ramesh Chandra and Arman Rahmim
Publisher: Wolters Kluwer (Nov. 2017; Philadelphia, PA)
Edition: 8th

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Wolters Kluwer

Overview: Part of the renowned The Basics series of medical physics books, and originally authored by Dr. Chandra decades ago, this has been a classic text for nuclear medicine, molecular imaging and radiology residents, fellows and practitioners, medical physicists and radiologic technologists. This newly co-authored effort has lead to a substantially updated and expanded 8th edition.

The book covers a wide range of topics on radioactivity, radiopharmaceuticals, in vitro and in vivo detection, radiation dosimetry/risk/regulations, imaging devices (gamma camera, SPECT, PET), quality assurance, image reconstruction/processing, etc., with 18 chapters:

  1. Basic Review
  2. Nuclides and Radioactive Processes
  3. Radioactivity: Law of Decay, Half-Life, and Statistics
  4. Production of Radionuclides
  5. Radiopharmaceuticals
  6. Interaction of High-Energy Radiation with Matter
  7. Radiation Dosimetry
  8. Detection of High-Energy Radiation
  9. In Vitro Radiation Detection
  10. In Vivo Radiation Detection: Basic Problems, Probes, and Scintillation Camera
  11. Computer Interfacing and Image Processing
  12. Operational Characteristics and Quality Control of a Scintillation Camera
  13. Emission computed tomography (ECT), General Principles
  14. Single-Photon Emission Computed Tomography (SPECT)
  15. Positron Emission Tomography (PET)
  16. Detectability or Final Contrast in an Image
  17. Biological Effects of Radiation and Risk Evaluation from Radiation Exposure
  18. Methods of Safe Handling of Radionuclides and Pertaining Rules and Regulations

Article on the promise of whole-body dynamic PET

Our efforts to translate the concept of dynamic whole-body imaging to the clinical arena are taking notice, as seen in this web article: “A clinical take on whole-body dynamic PET”. Our very own Nicolas Karakatsanis, who initiated these efforts as a post-doc in the lab, then pursued efforts in Geneva at the Zaidi Lab, and now at Mt Sinai, recently published the promising results of combining this novel acquisition protocol with advanced 4D image reconstruction to achieve improved quantitative imaging. Through our ongoing, close collaborations with Siemens Medical Solution, we are very optimistic about future implementation and promise of this framework.

A race effect on amyloid deposition?

Our recent publication in the journal Neurology has been accompanied by a nice editorial reviewing and discussing the novel finding. This work involved recruitment of subjects from the longitudinal Atherosclerosis Risk in Communities (ARIC) study, for  an additional PET scan to visualize amyloid in the brain, which has been a major breakthrough in the field of Alzheimer disease (AD). The resulting ARIC-PET amyloid imaging study revealed for the first time that black subjects depicted higher amyloid levels, even after adjustment for demographics, vascular risk factors, and cognitive status, making the provocative suggestion that there might be race differences in the process of amyloid deposition.

The analysis itself was stimulated by reports of increased prevalence of AD in black compared to white individuals. In this major NIH funded effort (PI: Gottesman), extensive site travel, quality assurance and quantitative analysis was performed by Chief Physicist Dr. Rahmim for data obtained from the three PET imaging sites (Washington County, MD; Jackson, MS; and Forsyth County, NC).

 

Why you can’t stop checking your phone?

Here’s a concise and helpful overview (by the Johns Hopkins Magazine) of the recent finding in our paper, “The Role of Dopamine in Value-Based Attentional Orienting.”

Quantitative Tomography Lab

Over the past years we have devoted significant efforts to implement routine, systematic motion compensation for  brain PET studies at our center. The following work, just published in Current Biology (led by our collaborator, the late Dr. Yantis), was only able to arrive at significant correlations between value-based distraction and PET-measured dopamine release after inclusion of motion compensation. We are quite motivated by these positive findings.

B. A. Anderson, H. Kuwabara, D. F. Wong, E. G. Gean, A. Rahmim, J R. Brasic , N. George, B. Frolov, S. M. Courtney, and S. Yantis
The role of dopamine in value-based attentional orienting
Current Biology, vol. 26, pp. 550-555, 2016.

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Motion correction framework at Hopkins resulted in significant findings

Over the past years we have devoted significant efforts to implement routine, systematic motion compensation for  brain PET studies at our center. The following work, just published in Current Biology (led by our collaborator, the late Dr. Yantis), was only able to arrive at significant correlations between value-based distraction and PET-measured dopamine release after inclusion of motion compensation. We are quite motivated by these positive findings.

B. A. Anderson, H. Kuwabara, D. F. Wong, E. G. Gean, A. Rahmim, J R. Brasic , N. George, B. Frolov, S. M. Courtney, and S. Yantis
The role of dopamine in value-based attentional orienting
Current Biology, vol. 26, pp. 550-555, 2016.